CAS No. 187389-53-3

Molecular Formula: C11H18FNO5
Molecular Weight: 263.263
WGKGermany: 3

Description:
BOC-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα). It has been found to reduce the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-kB), suppress the phosphorylation of subunit nuclear factor kappa light polypeptide gene enhancer in B cells inhibitor α (IkBα) and inhibit TNF-induced expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Moreover, it has also effectively attenuated the hepatocyte apoptosis in bile duct-ligated rats potentially improving the survival rates.

• Molecular Weight: 263.26
• Molecular Formula: C11H18FNO5

Purity: 95%

Canonical SMILES:
CC(C)(C)OC(=O)NC(CC(=O)OC)C(=O)CF

InChI:
InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1

InChIKey: MXOOUCRHWJYCAL-ZETCQYMHSA-N

• Boiling Point: 383.5±37.0°C (Predicted)
• Solubility: Slightly soluble in DMF, DMSO, Ethanol, PBS
• Appearance: Off-white crystalline Solid
• Application: Caspase Inhibitors
• Storage: Store at -20°C

Synonyms:
Boc-Asp(OMe)-fluoromethyl ketone; Caspase Inhibitor 3; N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone; BAF; Boc-D-Fluoromethyl Ketone; Boc-D(OMe)-FMK; 3S-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid, methyl ester; Caspase Inhibitor III

More details are to be found on supplier website